Genetic Susceptibility to Type 2 Diabetes and Implications for Therapy

نویسندگان

  • Asima Zia
  • Aysha Karim Kiani
چکیده

Diabetes mellitus is a chronic condition characterized by increased glucose level due to absence/insufficient insulin secretion (Figure 1). The old classification of diabetes divided it into juvenileand maturity-onset diabetes. Now an etiology based classification devised by the American Diabetes Association (ADA) and the World Health Organization (WHO) is used that divides diabetes into: type 1 diabetes (T1DM), type 2 diabetes (T2DM), monogenic diabetes, gestational diabetes,

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Genetic Polymorphisms of Estrogen Receptors in Iranian Women with Diabetes and Coronary Artery Disease

Estrogen might play an important role in the pathogenesis of diabetes mellitus type 2. Estrogens inhibit diabetes via distinct mechanisms particularly by reducing both hyperglycemia and plasma insulin levels. Estrogen exerts its physiological effects mainly through estrogen receptors including α and β types. Estrogen receptors are found in many tissues that participate in the pathogenesis of ty...

متن کامل

Genetic Susceptibility to Transient and Permanent Neonatal Diabetes Mellitus

Neonatal diabetes mellitus (NDM) is a rare kind of diabetes characterized by hyperglycemia and low levels of insulin. Clinically, it is categorized into two main types: transient NDM (TNDM) and permanent NDM (PNDM). These types are diagnosed based on duration of insulin dependence early in the disease. In TNDM, diabetes begins in the first few weeks of life with remission in a few months. Howev...

متن کامل

Single Nucleotide Polymorphism (SNP) in the Adiponectin Gene and Cardiovascular Disease

Dear Editor, The recent article by Mohammadzadeh et al.[1] on the latest issue of this Journal showed that the T allele +276G/T SNP of ADIPOQ gene is more associated with the increasing risk of coronary artery disease (CAD) in subjects with type 2 diabetes. Adipocytes were described in myocardial tissue of CAD patients and their role recently discussed[2,3]. Susceptibility to CAD by polymorp...

متن کامل

Genetic Epidemiology of Adult Onset Type 2 Diabetes in Asian Indian Population: Past, Present and Future

Incidence and prevalence of Type 2 Diabetes mellitus (T2DM) continue to rise in Indian populations. Despite known roles for obesity, sedentary lifestyles and diet, genetic predisposition accounts for significant risk. The identification of susceptibility loci for both monogenic and typical (oligogenic) diabetes have introduced novel genes, pathways and mechanisms of diabetes pathogenesis. Very ...

متن کامل

MAP3K1 May be a Promising Susceptibility Gene for Type 2 Diabetes Mellitus in an Iranian Population

Considering that MAPK (mitogen- activated protein kinase) signaling pathway has an important role in the progression of inflammatory cytokine secretion in type 2 diabetes mellitus (T2DM), we have recently investigated the reported genetic polymorphism from genome wide association study in MAP3K1 (mitogen-activated protein kinase kinase kinase 1) in diabetes as an important member of MAPK signal...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013